Representative Papers

1.          PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion, Cell Reports, 2023 May, 42(5) 

2.          Anticoagulation therapy promotes the tumor immune-microenvironment and potentiates the efficacy of immunotherapy by alleviating hypoxia’, J Immunother Cancer 

3.          BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells, Nature Immunology, 2021 July

4.          GITR agonism triggers antitumor immune responses through IL21-expressing follicular helper T cells, Cancer Immunol Res. 2020 Mar 2.

5.          Paradoxical association of TET loss of function with genome-wide DNA hypomethylation. Proc Natl Acad Sci U S A, Aug 20;116(34):16933-16942.

6.          TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion, Proc Natl Acad Sci U S A, 2019 Jun 

7.          NR4A transcription factors limit CAR T cell function in solid tumours, Nature 2019 Mar;567(7749):530-534.

8.          Activation of NKT cells in an anti-PD-1-resistant tumor model enhances anti-tumor immunity by reinvigorating exhausted CD8 T cells, Cancer Res, 2018, 18-0734 

9.          IL-21 therapy combined with PD-1 and Tim-3 blockade provides enhanced NK cell antitumor activity against MHC class I-deficient tumors. Cancer Immunol Res, 2018 

10.        IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours. Nature Communications. 2017 Jun 6;8:15776.